Table 3.
Risk of All-Cause and Respiratory Hospitalization in Patients with Interstitial Lung Disease
| Characteristic | Unadjusted (n = 1,094) |
Adjusted (n = 880) |
||||
|---|---|---|---|---|---|---|
| IRR | 95% CI | P Value | IRR | 95% CI | P Value | |
| All-cause hospitalization | ||||||
| MLN* ≥10 mm | 1.54 | 1.22–1.95 | <0.001 | 1.52 | 1.17–1.98 | 0.002 |
| PT MLN station* (stations 1–7) | 1.48 | 1.17–1.88 | 0.001 | 1.46 | 1.12–1.90 | 0.005 |
| LZ MLN station* (stations 8 and 9) | 2.67 | 1.62–4.41 | <0.001 | 3.52 | 2.02–6.13 | <0.001 |
| MLN count† | 1.55 | 1.25–1.93 | <0.001 | 1.51 | 1.19–1.93 | 0.001 |
| Respiratory hospitalization | ||||||
| MLN* ≥10 mm | 1.55 | 1.10–2.19 | 0.012 | 1.71 | 1.15–2.53 | 0.008 |
| PT MLN station* (stations 1–7) | 1.46 | 1.03–2.06 | 0.034 | 1.59 | 1.07–2.36 | 0.021 |
| LZ MLN station* (stations 8 and 9) | 3.19 | 1.61–6.30 | 0.001 | 4.58 | 2.11–9.96 | <0.001 |
| MLN count† | 1.63 | 1.18–2.24 | 0.003 | 1.63 | 1.14–2.33 | 0.007 |
Definition of abbreviations: CI = confidence interval; ILD = interstitial lung disease; IRR = incidence rate ratio; LZ = lower zone; MLN = mediastinal lymph node; PT = paratracheal.
Results are adjusted for sex, age, FVC, DlCO, ILD subtype, tobacco pack-years, body mass index, immunosuppressive therapy, and hospital center.
*
Compared to patients without any enlarged MLN (i.e., MLN <10 mm).
†
Comparing subjects with ≥2 MLN to subjects with <2 MLN.