Figure 1.

Phenotypic and genetic characterization of an adult-onset familial pulmonary fibrosis kindred. Individuals with pulmonary fibrosis or an unclassified lung disease are indicated by purple and blue symbols, respectively. Unfilled symbols represent individuals with no reported lung disease. The arrow indicates the proband. Numbers in parentheses indicated individuals for whom no DNA sample was available. Age in years at the time of blood draw or death is indicated to the right of each symbol. The genotypes of individual II.3 were inferred from the haplotypes of his children (data not shown). The pedigree was modified to protect the identities of the participants. Inset shows autozygous regions of chromosome 16 (red blocks) determined from the exome sequencing data of the proband (II.4).