Figure 2.

Dosage of PARN p.Arg444Cys variant associated with telomere shortening. Telomere length of genomic DNA isolated from circulating leukocytes from members of one family as measured by multiplexed quantitative PCR assay (7). Telomere lengths are adjusted for age and are expressed as the observed length minus the expected length. Each symbol represents a unique individual. White circles outlined in black represent unrelated spouses. Telomere lengths were significantly different across the three groups (zero, one, and two copies of the PARN allele) by one-way ANOVA (*P = 0.0006).