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. 2019 Mar 18;9:4824. doi: 10.1038/s41598-019-41208-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Fabrication and assembly of the spiral channel acrylic microfluidic devices with reconfigurable flow actuation mechanisms. A spiral microfluidic channel is laser ablated onto an acrylic board. Either a hydrophilic or a hydrophobic tape is applied to seal the channel. (b) Automatic pump-free flow actuation with the spiral acrylic microfluidic channel sealed by a hydrophilic tape. Water with green dye was dropped into the inlet at t = 0. The whole channel was automatically filled due to the passive capillary action at t = 20 s. (c) Finger-press flow actuation with the same spiral channel sealed by a hydrophobic tape. Water with green dye was dropped into the inlet at t = 0 and could not flow into the channel after 5 minutes because of the tape hydrophobicity, until actuated by a finger press on the inlet. The scale bar is 10 mm. The results in this figure were obtained with acrylic channels fabricated using the vector ablation method shown in Fig. 1 and can be repeated with channels made by raster ablation (data not shown).