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. 2019 Mar 12;10:155. doi: 10.3389/fneur.2019.00155

Figure 2.

Figure 2

Acetoacetic acid significantly inhibits the opening of acid-sensing ion channels in rat hippocampal neurons at pH 6.0. (A) The current wave amplitude of the acid-sensing ion channel at pH < 6.0 was rescued by the treatment with acetoacetic acid. The upper panels show typical recordings of the current wave amplitude of the acid-sensing ion channel. (B) The quantification of the average amplitude of the current is shown in the lower panel. Data are presented as the mean ± SEM. The number of rats is 3–4 and that of the neurons in the test is 8–10; ***P < 0.001.