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. 2019 Mar 12;10:155. doi: 10.3389/fneur.2019.00155

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Copyright © 2019 Zhu, Shan, Xu, Guo, Wu and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Acetone significantly inhibits the opening of acid-sensing ion channels in rat hippocampal neurons at pH 6.0. The current wave amplitude of the acid-sensing ion channel at pH < 6.0 was rescued by the treatment with acetone. (A) The upper panels show typical recordings of the current wave amplitude of acid-sensing ion channel. (B) The quantification of the average amplitude of the current is shown in the lower panel. Data are presented as mean ± SEM. The number of rats is 3–4 and that of the neurons in the test is 8–10; ***P < 0.001.