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. 2019 Mar 12;10:249. doi: 10.3389/fphys.2019.00249

FIGURE 2.

FIGURE 2

Meis1 and Meis2 expression patterns in molar and incisor formation. Frontal (A–C,E) and sagittal (D,F–I) sections of E12.5–E18.5 wild type mice. Meis1 is lowly expressed in the oral and dental epithelium at placode and bud stages (A,B,E,F). Its expression increases and becomes restricted to the cervical loops during cap and bell stages (C,D,G,H). Meis2 is strongly expressed in the oral epithelium and in the dental placode (A’,E’). Meis2 expression is restricted to the dental cord and vestibular lamina during the bud and cap stages (B’,C’,F’,G’). During bell stage, Meis2 is present in the proximal fraction of the molar (D’) but not in the incisor labial cervical loop (H’). In the adult incisor (P60), Meis1 is specifically expressed in the labial cervical loop, while Meis2 transcripts are no longer detected in the organ (I’). Scale bars 100 μm. Dashed line labels epithelial tissue.