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. 2019 Mar 18;9:10. doi: 10.1038/s41387-019-0076-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a, b Note the marked reduction in PVN NE levels in both DIO and DR rats, indicating normal responsiveness to exogenous leptin. c, d Decrease in ME CRH or serum corticosterone in DR rats following leptin injection is not observed in DIO rats. Bars with different notations are significantly different from each other (p < 0.05). * indicates significant difference from the rest of the groups (p < 0.05). 6–8 rats/group