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. 2019 Mar 18;9:4760. doi: 10.1038/s41598-019-41205-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Gene signatures of immunogenicity to Hantavax vaccination based on vaccine responsiveness. Transcriptomic data of the 2^nd (a), 3^rd (b), and 4^th (c) vaccinations relative to pre-vaccination. Numbers of more than two-fold up- or downregulated differentially expressed genes (DEGs) identified from the comparison of the control and virus-infected groups (DEGs were identified based on a false discovery rate (FDR) q-value threshold of less than 0.05). The volcano plot shows the DEG patterns for Hantavax vaccinees. (d) Vaccinees were classified into three groups based on vaccine responsiveness (i.e. HTNV neutralizing antibody titers): NRs (non-responders), LRs (low responders), and HRs (high responders). The volcano plot shows the DEGs identified based on a false discovery rate (FDR) q-value threshold of less than 0.05 for Hantavax vaccinees between HR vs NR & LR. The x-axis represents the log₂ values of the FC observed for each mRNA transcript, while the y-axis represents the –log₁₀ values of the p-values of the significance tests between replicates for each transcript. Data for genes that were not classified as defferentially expressed are plotted in black.