Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Mar 18;9:4760. doi: 10.1038/s41598-019-41205-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Pathway overview of nicotinate & nicotinamide metabolism, folate biosynthesis, and arachidonic acid metabolism correlated with the top DEGs. (a) Relative concentrations of significantly upregulated metabolites in nicotinate and nicotinamide metabolism pathways, detected before the 1^st and after the 2^nd, 3^rd, and 4^th vaccinations (all), correlated with the upregulated NAMPT and NADSYN1 genes after the 2^nd vaccination. (b) Relative concentrations of significantly upregulated metabolites in folate biosynthesis pathway detected before the 1^st and after the 2^nd, 3^rd, and 4^th vaccinations (all), correlated with the upregulated ALPL gene after the 2^nd and 4^th vaccinations. (c) Relative concentrations of significantly upregulated metabolites in arachidonic acid metabolism pathway detected before the 1^st and after the 2^nd, 3^rd, and 4^th vaccinations (all), correlated with the upregulated MS4A2 and ALOX5 genes after the 3^rd vaccination. ***p ≤ 0.001; **p ≤ 0.01; *p ≤ 0.05; ^ns, not significant (p > 0.05), per student’s t-test.