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. 2019 Mar 18;9:4805. doi: 10.1038/s41598-019-41285-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Protective efficacy conferred by vaccine strains in mice from lethal EV-A71 challenge. (a) Body weights were recorded for all 4-week old ICR mice after EV-A71 challenge until 10 days’ post-infection. Besides weight gain as an indicator of protective efficacy, other parameters such as alertness, activity and normal appetite were assessed. The results are expressed as the mean ± standard error of the mean of five mice. (b) Clinical scores of challenge with the EV-A71 MAV strain in 4-week old ICR mice inoculated with the pIY miRNA vaccine strain, MMS, and the IV. The control group was the mice administered with PBS but challenged with the mouse adapted virus (MAV) (n = 5).