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. 2019 Mar 18;9:4796. doi: 10.1038/s41598-019-40857-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MiR-145-5p decreases PTPRF which leads to lower STAT1 phosphorylation through direct binding of STAT1. (A) Expression of PTPRF by Western blot upon Allstars or miR-145-5p expression in different cell lines. Shown is one representative experiment. (B) Quantification of PTPRF expression normalized by GAPDH expression relative to AllStars control of each cell line (N = 3). (C) Two non-canonical coding sequence (CDS) binding sites, site #1 and site #2, in the PTPRF mRNA for miR-145-5p were identified. (D) Relative luciferase activity of two PTPRF-CDS-binding-site-reporters was measured. Results for both potential non-canonical binding sites, site #1 and site #2, are depicted in AllStars (Control) and miR-145-5p-mimic (miR-145)-transfected cells. ns: non-significant.