Table 2.

Clinical Characteristics and Outcome of B-ALL Cases with COBL Rearrangements

Patient	Clinical Trial	CNS Disease	MRD Day 33	MRD Day 78	PR	CMR Day 33	Relapse	Outcome	Follow-Up (Months)
P147	AALL0232_1	NA	NA	NA	NA	NA	NA	NA	NA
P068	AALL0331/UKALLR3	No	Negative	Negative	NA	Yes	BM	Dead	45
P034	AIEOP-BFM ALL2000	No	Negative	Negative	Good	Yes	No	1st CR	96
P022	AIEOP-BFM ALL2000	No	Negative	Negative	Good	Yes	No	1st CR	79
P114	AIEOP-BFM ALL2000	No	NA	NA	Good	Yes	NA	Dead	NA
P120	AIEOP-BFM ALL2000	No	Positive	Positive	Poor	No	No	Dead	4
P104	ALL IC 2009	Yes	Negative	Negative	Good	Yes	No	1st CR	38
P145	UKALL2003	No	Negative	Negative	NA	Yes	No	1st CR	105
P146	UKALL2003	No	Negative	NA	NA	Yes	BM, CNS	Dead	66
P144	UKALL97	No	NA	NA	NA	Yes	No	1st CR	26
P143	UKALL97	No	NA	NA	NA	Yes	No	1st CR	167
P003	CAALLF01	No	Negative	NA	Good	Yes	NA	1st CR	4
P079	COALL 05-92	No	NA	NA	NA	Yes	No	1st CR	161
P086	COALL 06-97	No	Negative	NA	NA	Yes	Testes	2nd CR	195
P074	COALL 06-97	No	Negative	NA	NA	Yes	BM	2nd CR	154
P069	COALL 07-03	No	Positive	NA	NA	No	No	1st CR	123
P004	EORTC 58081	No	Negative	Negative	Good	Yes	No	1st CR	49
P090	EsPhALL	No	Positive	NA	Good	Yes	Isolated BM	Dead	56
P006	FRALLE 93	No	Positive	Positive	Poor	Yes	Yes	Relapse	192
P002	FRALLE BT	No	Positive	Negative	Poor	Yes	No	1st CR	15
P122	GBTLIALL99	No	NA	NA	Good	Yes	NA	Alive	NA
P121	GBTLIALL99	No	Negative	Negative	Good	Yes	No	Alive	NA
P005	GRAAPH	No	Positive	Positive	Not evaluable	Yes	No	1st CR	27
P056	NA	No	Positive	NA	Good	Yes	BM	Lost follow-up	17
P001	NA	No	Positive	NA	Good	Yes	No	SCT; alive	9

BM, bone marrow; CNS, central nervous system; CMR, complete morphological remission; MRD, minimal residual disease; NA, not available; PR, prednisone response; SCT, stem-cell transplantation; WBC, white blood cell count. MRD-negative status was defined as <0.01% leukemic cells in bone marrow and peripheral blood.