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Crystal structures of LD. (A) The dimer arrangement of IRE1 LD from both yeast (PDB 2BE1) and human (PDB 2HZ6) proteins, with dimer interface marked by dashed line. (B) PERK LD dimer structure shares similar architecture to IRE1 LD. PERK LD has also been visualized in a tetramer arrangement comprising two sets of dimers (PDB 4YZS and 4YZY), and PERK LD bound to peptide (PDB 5V1D).
