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. 2019 Mar 12;6:11. doi: 10.3389/fmolb.2019.00011

Figure 4.

Figure 4

Crystal structures of IRE1 cytosolic domain. (A) Schematic depicting the IRE1 cytosolic portion in a face-to-face dimer (PDB 3P23) that enables trans autophosphorylation, and in a back-to-back arrangement (PDB 2RIO), which is suggested to be the RNase active state. The red arrow represents the transition between these two states. (B) A comparison of crystal structures of IRE1 RNase domain when bound to a kinase inhibitor that prevents both kinase and RNase activation (gold, PDB 4YZ9) and when bound to a kinase inhibitor that activates RNase domain (cyan, PDB 4YZC). The small movements within the domain are suggested to enhance splicing activity.