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. 2019 Mar;44(2):108–117.

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Copyright: © Iranian Journal of Medical Sciences

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of silymarin on liver oxidative stress parameters. The results are expressed as means±SDs. Liver MDA (A), TTM (B), TOS (C), TAC (D) and OSI (E) contents. C: Control; S: Silymarin; D: Diabetic; MDA: Malondialdehyde; TTM: Total thiol molecule; TOS: Total oxidant status; TAC: Total antioxidant capacity; OSI: Oxidative stress index; aSignificant compared to the healthy control group; bSignificant compared to the diabetic control group; Significant difference between the diabetic and control groups in the all the parameters (P<0.001) Significant difference between the diabetic rats treated with silymarin (60 and 120 mg/kg) and the diabetic group in MDA, TOS, and OSI (P= 0.00), TAC (P=0.04 and P=0.01), and TTM (P=0.01 and P<0.001)