Table 2:

Multivariable-adjusted Relative Risks of ALS by quartile of plasma urate determined by enzyme assay

	Quartile 1 (ref)	Quartile 2	Quartile 3	Quartile 4	§p-trend	1 mg/dL increase
Men
Urate mg/dL, cut-points (median)	<=5.1 (4.4)	<=5.9 (5.5)	<=6.6 (6.4)	>6.6 (7.7)
No. of controls	37	36	41	36
No. of cases	20	25	17	13
Age, matching, adjusted RR* (95% CI)a	Ref	1.25 (0.59,2.66)	0.76(0.34,1.70)	0.65 (0.26,1.59)	0.18	0.86 (0.69,1.07)
Multivariable adjusted RR (95% CI)b	Ref	1.23 (0.58,2.62)	0.77 (0.35,1.73)	0.68 (0.28,1.69)	0.24	0.87 (0.70,1.09)
Multivariable adjusted RR (95% CI)c	Ref	0.89 (0.39,2.03)	0.60 (0.26,1.43)	0.51 (0.19,1.39)	0.10	0.78 (0.60,1.01)
Women
Urate mg/dL, cut-points (median)	<=3.9 (3.5)	<=4.6 (4.3)	<=5.6 (5.1)	>5.6 (6.3)
No. of controls	102	90	106	100
No. of cases	57	55	46	41
Age, matching, adjusted RR* (95% CI)a	Ref	1.08 (0.67,1.74)	0.76 (0.47,1.25)	0.72 (0.45,1.18)	0.11	0.89 (0.78,1.03)
Multivariable adjusted RR (95% CI)b	Ref	1.14 (0.71,1.85)	0.84 (0.50,1.41)	0.84 (0.50,1.42)	0.36	0.94 (0.80,1.09)
Multivariable adjusted RR (95% CI)c	Ref	1.15 (0.71,1.86)	0.84 (0.50,1.41)	0.83 (0.49,1.41)	0.34	0.93 (0.80,1.09)
Men and Women
Age, matching, adjusted RR* (95% CI)a	Ref	1.13 (0.75,1.69)	0.76 (0.50,1.16)	0.71 (0.46,1.08)	0.039	0.88 (0.78,0.997) p=0.044
Multivariable adjusted RR (95% CI)b	Ref	1.17 (0.78,1.75)	0.82 (0.53,1.27)	0.80 (0.51,1.25)	0.16	0.91 (0.80,1.04) p=0.166
Multivariable adjusted RR (95% CI)c	Ref	1.07 (0.71,1.63)	0.77 (0.50,1.20)	0.75 (0.47,1.19)	0.097	0.89 (0.78,1.02) p=0.081

^a.Adjusted for age (years) and sex, and matching factors

^b.add body mass index

^c.add smoking status (never, past, current), education level (<high school, high school, >high school).

^*RR: relative risk, CI, confidence interval.

^§P-trend calculated using median value for each quartile.