Table 3:
Yearly Rate of Weight (kg) Gain from Early Adulthood to Enrollment by Cohort and Risk of ALS Death
| Cohort | Continuous yearly weight gain per 1kg Increment |
Quartile 1 Median (10th–90th percentile) RR (95% CI) |
Quartile 2 Median (10th–90th percentile) RR (95% CI) |
Quartile 3 Median (10th–90th percentile) RR (95% CI) |
Quartile 4 Median (10th–90th percentile) RR (95% CI) |
|---|---|---|---|---|---|
| Women | |||||
| IWHS | RR=0.29 (95% CI: 0.12, 0.71), p=0.007 |
0.03 (−1.17, 0.13) Ref |
0.21 (0.15, 0.27) RR=0.82 (95% CI:0.49, 1.39) |
0.37 (0.30, 0.45) RR=0.51 (95% CI:0.28, 0.93) |
0.63 (0.50, 0.96) RR=0.43 (95% CI:0.21, 0.80) |
| MCCS | RR=0.51 (95% CI: 0.06, 4.35), p=0.54 |
0.04 (−0.18, 0.13) Ref |
0.24 (0.17, 0.31) RR=1.63 (95% CI:0.43, 6.13) |
0.42 (0.35, 0.51) RR=1.30 (95% CI:0.29, 5.83) |
0.74 (0.57, 1.18) RR=0.47 (95% CI:0.05, 4.68) |
| NLCS | RR=0.36 (95% CI: 0.06, 2.11), p=0.260 |
0 (−0.21, 0.08) Ref |
0.16 (0.11, 0.21) RR=0.49 (95% CI:0.22, 1.07) |
0.29 (0.23, 0.35) RR=0.29 (95% CI:0.12, 0.70) |
0.49 (0.38, 0.73) RR=0.58 (95% CI:0.25, 1.35) |
| PLCO | RR=0.47 (95% CI: 0.10, 2.18), p=0.333 |
0.06 (−0.11, 0.14) Ref |
0.23 (0.17, 0.29) RR=1.32 (95% CI:0.51, 3.14) |
0.40 (0.32, 0.48) RR=0.67 (95% CI:0.21, 2.13) |
0.68 (0.53, 1.07) RR=0.64 (95% CI:0.18, 2.25) |
| SMC | RR=0.47 (95% CI: 0.10, 2.26), p=0.344 |
0.03 (−0.61, 0.11) Ref |
0.20 (0.14, 0.25) RR=1.21 (95% CI:0.50, 2.92) |
0.34 (0.28, 0.42) RR=1.20 (95% CI:0.47, 3.04) |
0.57 (0.45, 0.89) RR=0.70 (95% CI:0.23, 2.19) |
| WLHS | RR=0.55 (95% CI: 0.11, 2.77), p=0.467 |
0 (−0.38, 0.11) Ref |
0.23 (0.16, 0.31) RR=1.75 (95% CI: 0.42, 7.27) |
0.43 (0.35, 0.53) RR=1.95 (95% CI: 0.47, 1.21) |
0.78 (0.60, 1.33) RR=0.34 (95% CI: 0.03, 3.45) |
|
Pooled |
RR=0.38 (95% CI: 0.21, 0.68), p=0.001 |
Ref |
RR=0.91 (95% CI:0.65, 1.28), p=0.59 P for heterogeneity=0.4 |
RR=0.70 (95% CI:0.41, 1.21), p=0.20 P for heterogeneity=0.13 |
RR=0.51 (95% CI:0.33–0.78), p=0.002 P for heterogeneity=0.92 |
| Men | |||||
| COSM | RR=0.65 (95% CI: 0.20, 2.18), p=0.487 |
0.04 (−0.12, 0.12) Ref |
0.20 (0.15, 0.26) RR=0.74 (95% CI:0.37, 1.46) |
0.35 (0.29, 0.43) RR=0.57 (95% CI:0.26, 1.25) |
0.60 (0.47, 0.92) RR=1.03 (95%CI: 0.49, 2.16) |
| MCCS | RR=0.04 (95% CI: 0.00, 0.52), p=0.013 |
0.06 (−0.13, 0.15) Ref |
0.26 (0.19, 0.33) RR=1.11 (95% CI: 0.34, 3.66) |
0.44 (0.36, 0.53) RR=0.15 (95% CI: 0.02, 1.38) |
0.74 (0.58, 1.13) RR=0.17 (95% CI:0.02, 1.71) |
| NLCS | RR=0.43 (95% CI: 0.09, 2.12), p=0.303 |
0 (−0.15, 0.08) Ref |
0.16 (0.11, 0.21) RR=0.67 (95% CI:0.32, 1.43) |
0.28 (0.23, 0.33) RR=0.74 (95% CI:0.33, 1.66) |
0.49 (0.38, 0.71) RR=0.66 (95% CI:0.25, 1.74) |
| PLCO | RR=0.23 (95% CI: 0.05, 1.13), p=0.070 |
0.05 (−0.13, 0.13) Ref |
0.22 (0.16, 0.28) RR=0.86 (95% CI:0.36, 2.03) |
0.38 (0.31, 0.45) RR=0.49 (95% CI:0.18, 1.39) |
0.63 (0.50, 0.97) RR=0.35 (95% CI:0.10, 1.17) |
|
Pooled |
RR=0.32 (95% CI: 0.13, 0.83), p=0.018 |
Ref |
RR=0.78 (95% CI:0.52, 1.18), p=0.24 P for heterogeneity=0.91 |
RR=0.56 (95% CI:0.34, 0.90), p=0.017 P for heterogeneity=0.59 |
RR=0.63 (95% CI:0.37, 1.09), p=0.10 P for heterogeneity=0.37 |
|
All pooled |
RR=0.37 (95% CI: 0.23, 0.59), p<0.001 |
Ref |
RR=0.85 (95% CI:0.66, 1.11), p=0.24 P for heterogeneity=0.75 |
RR=0.62 (95% CI:0.44, 0.86), p=0.005 P for heterogeneity=0.30 |
RR=0.56 (95% CI:0.40, 0.78), p=0.001 P for heterogeneity=0.86 |
Multivariable RRs were adjusted for smoking status (ever smoking and smoking pack years <10, 10–<20, 20–<30, 30–<40, 40+), level of education attained (<high-school, high-school, >high-school), physical activity (low, moderate, high), and race (if appropriate to the cohort); age in years and year of questionnaire return were included as stratification variables.