Table 1.
Characteristics | Sinus rhythm (n=56) | Persistent AFa (n=52) | P value | |
Demographics | ||||
Age (years), mean (SD) | 58 (14.78) | 66.56 (13.17) | .002 | |
Female, n (%) | 26 (46) | 19 (37) | .30 | |
Body mass index (kg/m2), mean (SD) | 24.44 (2.88) | 25.98 (3.97) | .02 | |
Medical history | ||||
Heart failure, n (%) | 2 (4) | 12 (23) | .006 | |
Hypertension, n (%) | 29 (52) | 35 (67) | .10 | |
Diabetes mellitus, n (%) | 15 (27) | 17 (33) | .50 | |
Previous stroke/SEb/TIAc, n (%) | 4 (7) | 9 (17) | .19 | |
Coronary artery disease, n (%) | 25 (45) | 19 (37) | .39 | |
Vascular disease, n (%) | 31 (55) | 37 (71) | .09 | |
COPDd, n (%) | 1 (2) | 3 (6) | .56 | |
Renal dysfunction, n (%) | 2(4) | 8 (15) | .07 | |
Hepatic dysfunction, n (%) | 0 | 2 (4) | .23 | |
Sleep apnea, n (%) | 2 (4) | 6 (12) | .22 | |
Hyperthyroidism, n (%) | 1 (2) | 4 (8) | .32 | |
Current smoking, n (%) | 16 (29) | 17 (33) | .64 | |
Current drinking, n (%) | 13 (21) | 11 (23) | .80 | |
CHA2DS2-VASce score, median (IQRf) | 2 (1-3.75) | 3 (2-5) | .003 | |
HAS-BLEDg score, median (IQR) | 1 (0-2) | 2 (1-2) | .005 | |
Medications, n (%) | ||||
Oral anticoagulant | 10 (18) | 40 (77) | <.001 | |
Antiplatelet drug | 15 (27) | 23 (44) | .06 | |
Calcium channel blockers | 17 (30) | 13 (25) | .54 | |
ACEI/ARBh | 21 (38) | 16 (31) | .46 | |
Diuretic | 5 (9) | 13 (25) | .03 | |
Digoxin | 3 (5) | 11 (21) | .02 | |
Antiarrhythmic drug, n (%) | ||||
Class I | 6 (11) | 2 (4) | .32 | |
Beta blocker | 27 (48) | 34 (65) | .07 | |
Class III | 3 (5) | 20 (38) | <.001 | |
Class IV | 3 (5) | 3 (6) | >.99 |
aAF: atrial fibrillation.
bSE: systemic arterial embolism.
cTIA: transient ischemic attack.
dCOPD: chronic obstructive pulmonary disease.
eCHA2DS2-VASc: congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, stroke (doubled), vascular disease, age 65-74, female sex.
fIQR: interquartile range.
gHAS-BLED: hypertension, abnormal renal function, abnormal liver function, stroke, bleeding, labile INR, age >65 years, drugs or alcohol.
hACEI/ARB: angiotensin-converting-enzyme inhibitor, angiotensin receptor blockers.