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. 2019 Mar 12;10:481. doi: 10.3389/fimmu.2019.00481

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Copyright © 2019 Teige, Mårtensson and Frendéus.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Antibody-induced antitumor immunity can be enhanced by modulation of antibody: FcγR interactions. Left panel (no antibody checkpoint modulation). Antibody efficacy is balanced by co-engagement of activating and inhibitory FcγR. Center panel (enhanced engagement of activating FcγR). Antibody efficacy is improved through Fc-engineering for enhanced binding to activating FcγR. Right panel–Antibody efficacy is enhanced by blockade of the inhibitory FcγRIIB.