Fig. 1.

Principal component analysis of proteome data set from nitro resistantG. lambliatrophozoites (C4, 10621D10, 713M3) and their corresponding wild-types (WBC6, 106, 713). Trophozoites of the resistant strains were grown in the presence of 50 μM metronidazole (MET; red symbols) or 50 μM nitazoxanide (NTZ; blue symbols) and compared to their respective wild-types (green symbols) by MS shotgun analysis as described in Materials and methods. For each strain, all technical and biological (square, circle, diamond) replicates are shown. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)