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. 2019 Mar 17;12(5):764–774. doi: 10.1016/j.tranon.2019.02.014

Figure 5.

Figure 5

Decreased gene mutations in sensitive MBC patients (n=8). Dark blue represents the most common decreased mutations in sensitive patients.

(A) In ER-positive /HER2-negative therapy-sensitive patients (n=3), the frequencies of mutations in ESR1 (ID=15) and PIK3CA (ID=15, 35) decreased.

(B) In ER-positive /HER2-positive non-PD patients (n=5), the frequencies of mutations in PIK3CA decreased in three patients (ID=28, 30, 38). Two patients had decreases in the frequencies of RAF1 and SF3B1 gene mutation.