Table 2.
In vitro antibacterial activity of β-carboline chalcones 12a–g and their bromides 13a–i against a panel of bacterial strains.
 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Compd | Ar | R | Gram positive | Gram negative | ||||||
| B. subtilis | S. aureus | E. cloacae | E. coli | P. aeruginosa | ||||||
| ZOI (mm) | MIC (μM) | ZOI (mm) | MIC (μM) | ZOI (mm) | MIC (μM) | ZOI (mm) | ZOI (mm) | |||
| 12a | C6H5 | 9 | 838 | - | - | - | - | - | - | |
| 12b | 4-CH3C6H4 | 12 | 720 | 10 | 820 | 10 | 828 | - | - | |
| 12c | 4-CH3OC6H4 | 8 | 885 | 12 | 733 | 9 | 846 | - | 8 | |
| 12d | 3,4-(CH3O)2C6H3 | ND | ND | ND | ND | ND | ND | ND | ND | |
| 12e | 3,4,5-(CH3O)3C6H2 | - | - | 7 | >900 | 10 | 834 | - | - | |
| 12f | 4-CF3C6H4 | - | - | 11 | 710 | 11 | 726 | 10 | - | |
| 12 g | 4-(CH3)2NC6H4 | 8 | 870 | 11 | 715 | 8 | 880 | 8 | - | |
| 13a | 4-CH3OC6H4 | Benzyl | 8 | 875 | 15 | 440 | 8 | 874 | 8 | - |
| 13b | 4-CH3OC6H4 | n-Butyl | - | - | 9 | - | - | - | - | - |
| 13c | 4-CH3OC6H4 | Propargyl | - | - | 9 | - | 6 | - | - | 7 |
| 13d | 3,4-(CH3O)2C6H3 | Benzyl | 6 | - | 7 | - | 8 | - | - | - |
| 13e | 3,4-(CH3O)2C6H3 | n-Butyl | 7 | - | 9 | - | - | - | - | |
| 13f | 3,4-(CH3O)2C6H3 | Propargyl | 7 | - | 9 | - | 6 | - | - | 7 |
| 13 g | 3,4,5-(CH3O)3C6H2 | Benzyl | 7 | - | 9 | - | 12 | 726 | - | - |
| 13 h | 3,4,5-(CH3O)3C6H2 | n-Butyl | - | - | 10 | 812 | 10 | 806 | 8 | 12 |
| 13i | 3,4,5-(CH3O)3C6H2 | Propargyl | - | - | 9 | - | 13 | 590 | - | 9 |
| Chloramphenicol | 22 | 32 | 22 | 17 | 20 | 24 | 22 | 21 | ||
*
ZOI (in mm) and MIC (in μg/mL) values. Assay experiments were performed in duplicates at two independent times