Table III.
Top 10 downregulated and upregulated differentially expressed mRNAs in NOP2/Sun domain family member 2-deficient HepG2 cells compared with normal controls.
| A, Downregulated | |||
|---|---|---|---|
| Gene | Gene symbol | log2 fold change | P-value |
| ENSG00000135373 | EHF | −7.352147492 | 2.47×10−72 |
| ENSG00000175874 | CREG2 | −7.111981449 | 5.31×10−88 |
| ENSG00000079308 | TNS1 | −6.554792085 | 4.72×10−153 |
| ENSG00000121797 | CCRL2 | −6.440975865 | 9.08×10−66 |
| ENSG00000161249 | DMKN | −6.403903015 | 4.81×10−41 |
| ENSG00000154997 | SEPT14 | −6.158418718 | 1.14×10−89 |
| ENSG00000127324 | TSPAN8 | −6.069707964 | 4.77×10−40 |
| ENSG00000178172 | SPINK6 | −5.636422774 | 8.06×10−36 |
| ENSG00000078098 | FAP | −5.556570307 | 6.05×10−189 |
| ENSG00000099998 | GGT5 | −5.544869611 | 2.19×10−40 |
| B, Upregulated | |||
| Gene | Gene symbol | log2 fold change | P-value |
| ENSG00000147246 | HTR2C | 5.306442373 | 1.95×10−31 |
| ENSG00000124253 | PCK1 | 5.524179098 | 1.08×10−30 |
| ENSG00000121904 | CSMD2 | 5.563322974 | 1.17×10−27 |
| ENSG00000164128 | NPY1R | 5.880433118 | 8.29×10−44 |
| ENSG00000105894 | PTN | 6.248807612 | 1.27×10−35 |
| ENSG00000163530 | DPPA2 | 6.323234879 | 3.53×10−49 |
| ENSG00000125740 | FOSB | 7.352207927 | 4.93×10−41 |
| ENSG00000170345 | FOS | 7.442578093 | 3.12×10−43 |
| ENSG00000006611 | USH1C | 7.895447434 | 1.58×10−51 |
| ENSG00000135346 | CGA | 10.37870244 | 2.89×10−77 |