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. 2019 Jan 30;19(4):2953–2959. doi: 10.3892/mmr.2019.9915

Figure 1.

Figure 1.

Effect on FGF15 expression in mouse ileum. (A) Expression levels of ileal FGF15 mRNA were decreased in a dose-dependent manner by treatment with Dex for 24 h. (B) Expression of FGF15 mRNA was completely suppressed following consecutive treatment with 80 mg/kg Dex for 1–3 days. **P<0.01 vs. vehicle. (C) Dex diminished the induction of FGF15 by CA (200 mg/kg) in vivo. (D) Dex diminished the induction of FGF15 by treatment with CA (100 µg/ml) in the ileum culture ex vivo. The data were normalized to the expression levels of mouse U36B4. The data are presented as the mean ± standard deviation. n=3. *P<0.05, ***P<0.001. FGF15, fibroblast growth factor 15; Dex, dexamethasone; CA, cholic acid; N.D., not detectable.