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. 2019 Jan 30;19(4):2953–2959. doi: 10.3892/mmr.2019.9915

Figure 3.

Figure 3.

Suppression of FGF15 expression by Dex is potentially mediated by GR activation in the ileum. (A) GR activation by Dex (80 mg/kg) for 24 h induced CYP3A11 expression and suppressed the expression of FXR target genes (SHP, FGF15 and IBABP); however, did not affect FXR expression in the ileum. (B) PXR activation by PCN (25 mg/kg) for 24 h additionally induced CYP3A11 expression; however, did not affect the expression of FXR target genes (FGF15 and IBABP). The data were normalized to the expression levels of mouse U36B4. The data are presented as the mean ± standard deviation. n=3. *P<0.05, **P<0.01, ***P<0.001 vs. respective vehicle. FGF15, fibroblast growth factor 15; Dex, dexamethasone; GR, glucocorticoid receptor; CYP3A11, cytochrome P450, family 3, subfamily a, polypeptide 11; FXR, farnesoid X receptor; SHP, small heterodimer partner; IBABP, ileum bile acid binding protein; PXR, pregnane X receptor; PCN, pregnenolone-16-α-carbonitrile.