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. 2019 Feb 19;19(4):3087–3094. doi: 10.3892/mmr.2019.9968

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Copyright: © Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — PADI4 was involved in the process of EMT. (A) Knockdown of PADI4 increased the expression of epithelial makers (E-cadherin) and reduced the expression of mesenchymal markers (N-cadherin and vimentin). (B) The statistical chart represents the relative protein expression levels. (C) Knockdown of PADI4 reduced the EMT-associated Snail1/Smad3/4 transcriptional factors compared with the control group. (D) The statistical analysis represents the relative protein expression levels. Differences among groups were analyzed by one-way analysis of variance, followed by Bonferroni's multiple comparison test. *P<0.05 or **P<0.01 vs. control, n=3. N, neural; E, epithelial; EMT, epithelial-mesenchymal transition; PADI4, protein-arginine deiminase type-4; Smad, mothers against decapentaplegic homolog; Ctrl, control; NC, negative control.