TABLE 1.
Difference scores for acute administration of drug or drug combinations to reduce repetitive behavior
Difference scores represent the number of repetitive behavior counts observed in the 60 minutes following injection minus the number of repetitive behavior counts observed in the 60 minutes preceding injection. Values are mean (S.E.M.).
| Cohort | n | Drug(s) | Dose(s) (mg/kg) | Vehicle Difference Score | Drug Difference Score | P Value |
|---|---|---|---|---|---|---|
| 1-1 | 13 | D2 antagonist (L-741,626) | 3 | 209 (275) | 451 (259) | 0.59 |
| 1-2 | 9 | D2 antagonist | 10 | 789 (332) | 231 (278) | 0.37 |
| 1-3 | 13 | D2 antagonist | 30 | 256 (235) | −83 (264) | 0.30 |
| 1-4 | 11 | mGlu5 PAM (CDPPB) | 3 | 94 (280) | −268 (204) | 0.53 |
| 30 | −55 (283) | |||||
| 1-5 | 12 | A2A agonist (CGS21680) | 0.05 | −199 (205) | −324 (226) | 0.54 |
| 1-6 | 12 | D2 antagonist + A2A agonist | 30 + 0.05 | 44 (254) | −401 (382) | 0.37 |
| 1-7 | 13 | A2A agonist + mGlu5 PAM | 0.05 + 30 | 451 (213) | −307 (297) | 0.07 |
| 1-8 | 12 | D2 antagonist + mGlu5 PAM | 30 + 30 | 35(169) | −376 (187) | 0.15 |
| 1-9 | 12 | D2 antagonist + A2A agonist + mGlu5 PAM | 30 + 0.05 + 30 | 727 (237) | −703 (206) | 0.002 |