TABLE 2.
Difference scores for acute administration of drug or drug combinations to increase repetitive behavior
Difference scores represent the number of repetitive behavior counts observed in the 30 minutes following injection minus the number of repetitive behavior counts observed in the 30 minutes preceding injection. Values are mean (S.E.M.).
| Cohort | n | Drug(s) | Dose(s) (mg/kg) | Vehicle Difference Score | Drug Difference Score | P Value |
|---|---|---|---|---|---|---|
| 2-1 | 6 | D2 agonist (quinpirole) | 3 | −258 (230) | −207 (131) | 0.79 |
| 2-2 | 6 | mGlu5 NAM (MTEP) | 5 | −26 (176) | −222 (160) | 0.47 |
| 2-3 | 7 | A2A antagonist (SCH58261) | 1 | −86 (87) | −121 (139) | 0.76 |
| 2-4 | 6 | D2 agonist + A2A antagonist | 3 + 1 | −286 (106) | −781 (389) | 0.17 |
| 2-5 | 6 | A2A antagonist + mGlu5 NAM | 1 + 5 | −224 (92) | −14 (187) | 0.15 |
| 2-6 | 6 | D2 agonist + mGlu5 NAM | 3 + 5 | −85 (101) | 85 (220) | 0.60 |
| 2-7 | 7 | D2 agonist + A2A antagonist + mGlu5 NAM | 3 + 1 + 5 | −24 (173) | 387 (48) | 0.0497 |