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. 2019 Feb 25;19(4):3217–3229. doi: 10.3892/mmr.2019.9985

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Copyright: © Meng et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Paeonol reduces the number of mast cells in the dermis, and the concentration of IgE and inflammatory cytokines in the serum. (A) Mast cell infiltration in the dorsal skin was determined using toluidine blue staining (magnification, ×200; scale bar, 50 µm). Red arrows indicate the stained mast cells. (B) Mast cell counts in the different groups. Serum levels of (C) IgE, and the inflammatory cytokines (D) IL-4 and (E) histamine in the different groups, as measured using an ELISA. Data are presented as the means ± standard deviation (n=8). *P<0.05, **P<0.01 vs. the control group; ^#P<0.05, ^##P<0.01 vs. the model group. IgE, immunoglobulin E; IL-4, interleukin-4; Pae-H, paeonol-high (200 mg/kg); Pae-L, paeonol-low (50 mg/kg); Pae-M, paeonol-medium (100 mg/kg); Pred, prednisolone.

Figure 5. — Paeonol reduces the number of mast cells in the dermis, and the concentration of IgE and inflammatory cytokines in the serum. (A) Mast cell infiltration in the dorsal skin was determined using toluidine blue staining (magnification, ×200; scale bar, 50 µm). Red arrows indicate the stained mast cells. (B) Mast cell counts in the different groups. Serum levels of (C) IgE, and the inflammatory cytokines (D) IL-4 and (E) histamine in the different groups, as measured using an ELISA. Data are presented as the means ± standard deviation (n=8). *P<0.05, **P<0.01 vs. the control group; ^#P<0.05, ^##P<0.01 vs. the model group. IgE, immunoglobulin E; IL-4, interleukin-4; Pae-H, paeonol-high (200 mg/kg); Pae-L, paeonol-low (50 mg/kg); Pae-M, paeonol-medium (100 mg/kg); Pred, prednisolone.