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. 2019 Jan 31;19(4):2489–2496. doi: 10.3892/mmr.2019.9916

Figure 1.

Figure 1.

JMJD2A is highly expressed in cervical cancer cells and strongly associated with survival rate. (A) JMJD2A mRNA levels are upregulated in HeLa, CaSki, C-4-I, SiHa and C-33 A human cervical cancer cell lines. Normal and cancerous cervical cells were subjected to reverse transcription-quantitative polymerase chain reaction to detect the mRNA levels of JMJD2A. ***P<0.001 vs. the normal control. (B) JMJD2A is upregulated in HeLa, CaSki, C-4-I, SiHa and C-33 A human cervical cancer cell lines. Representative western blotting results are shown. Kaplan-Meier survival rate analysis demonstrates that (C) overall survival rate and (D) disease-free survival rates were lower in cervical cancer patients with higher JMJD2A expression. The mean JMJD2A level of the cervical cancer tissues was evaluated using western blotting. Cases with a JMJD2A level lower than the mean were enrolled in the JMJD2A low group, while the others were enrolled in the JMJD2A high group. Data are presented as the mean ± standard error of the mean. JMJD2A, jumonji domain containing 2A.