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. 2019 Jan 31;19(4):2489–2496. doi: 10.3892/mmr.2019.9916

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — miR-491-5p knockdown reverses the effects of sh-JMJD2A on cervical cancer cells. miR-491-5p knockdown reversed the effects of sh-JMJD2A on cell number in the cervical cancer cell lines (A) HeLa, (B) C-4-I and (C) SiHa. The cell numbers were evaluated at 0, 24, 48 and 72 h post-transfection. (D) miR-491-5p knockdown reversed the effects of sh-JMJD2A on cervical cancer colony number. The number of colonies was analyzed at 2 weeks after transfection. (E) miR-491-5p knockdown reversed the effects of sh-JMJD2A on cervical cancer cell apoptosis. Apoptotic rates were evaluated 2 weeks after transfection. Data are presented as the mean ± standard error of the mean. *P<0.05, **P<0.01 and ***P<0.001 vs. sh-NC + LNA-NC; ##P<0.01 and ###P<0.001 vs. sh-JMJD2A + LNA-NC. JMJD2A, jumonji domain containing 2A; sh, short hairpin; Ad, adenovirus; NC, negative control.