Table 2.

Univariate of factors associated with overall survival (n = 160)

Variables	Hazard ratio	95% confidence interval	P value
Age (> 45 vs ≤ 45)	0.739	0.437–1.249	0.258
Gender (male vs female)	0.995	0.561–1.764	0.986
Tumor differentiation (III–IV vs I–II)	2.267	1.339–3.837	0.002*
Tumor size, cm (> 5 vs ≤ 5)	0.997	0.587–1.694	0.991
HBsAg (positive vs negative)	0.865	0.461–1.624	0.652
Liver cirrhosis (positive vs negative)	1.025	0.619–1.695	0.925
Tumor encapsulation (none vs complete)	1.155	0.704–1.893	0.568
Child–Pugh score (B vs A)	0.767	0.466–1.260	0.295
Microvascular invasion (positive vs negative)	1.852	1.019–3.368	0.043*
AFP, ng/ml (> 50 vs ≤ 50)	1.431	0.730–2.803	0.297
TNM stage (III–IV vs I–II)	0.549	0.319–0.945	0.030*
Tumor number (multiple vs single)	0.690	0.403–1.180	0.175
MKP-4 (low vs high)	0.145	0.069–0.304	< 0.001*
ERK1/2 (low vs high)	2.377	1.226–4.610	0.010*
p-ERK1/2 (low vs high)	2.874	1.500–5.507	0.001*

Statistical analyses were performed using log-rank test

* P < 0.05 was considered significant