Fig. 5.

Reduced CD1c⁺ myeloid dendritic cell numbers but with increased p38 activation are found in the blood of CRPS participants compared to healthy controls. a A bar graph showing the number of cells in FlowSoM clusters representing the three major dendritic cell populations; CD1c⁺ mDCs (HLA-DR⁺CD14⁻CD11c⁺CD1c⁺CD141⁻), CD141⁺ mDCS (HLA-DR⁺CD14⁻CD11c⁺CD141⁺CD1c⁻) and plasmacytoid DCS (pDCs, HLA-DR⁺CD14⁻CD123⁺) in CRPS and control participants. b Intracellular signalling and functional marker expression levels in the FlowSoM cluster representing CD1c⁺ mDCs. N = 14 CRPS and N = 14 controls. All data are presented as group means (± S.E.M.). ^## represents P < 0.01 in a Mann-Whitney U Test