Fig. 5.

Emodin exhibits neutrophil-regulating capacity in a Lewis lung cancer allograft model. a Tumor appearance. b The curve of tumor growth (n = 10). c The relative tumor proliferation (n = 10). d Hypercoagulation indicated by platelet counts, platelet aggregation, fibrinogen (FIB), prothrombin time (PT), activated partial thromboplastin time (APTT) and bleeding time(BT)(n = 6). e CD66b+ cells in intratumor neutrophils analyzed using fluorescent cell count (n = 5). f The protein expression in intratumor neutrophils examined by western blot (n = 3). The data present Mean ± SD, the experiments were repeated 3 times, and statistical significance was determined by a t-test. *P < 0.05, **P < 0.01 vs control