Table 3.
Comparison of concentrations of five cytokines between participants with and without poor prognostic factors (N = 27)
| Cytokine/GF protein (pg/mL) | Poor prognostic factors | Low | High | * P-value |
|---|---|---|---|---|
| G-CSF | BMI | 19.6 (16–42.5) | N/A | NS |
| min LOD: 16 | Alb | 54.8 (25.8–70.1) | N/A | NS |
| max LOD: 10000 | CRP | N/A | 21.5 (16–66.7) | NS |
| Hb | 35.6 (16–125.8) | N/A | NS | |
| IL-1RA | BMI | 28.2 (10.5–63.9) | 17.4 (3.2–24.9) | NS |
| min LOD: 3.2 | Alb | 43.2 (22.5–144.4) | 19.6 (3.2–30.1) | < 0.05 |
| max LOD 10000 | CRP | 15.5 (3.2–46.2) | 29.1 (17.3–43.2) | NS |
| Hb | 29.1 (12.9–38.0) | 19.6 (3.2–57.5) | NS | |
| IL-10 | BMI | 1.0 (0.64–4.2) | 1.3 (0.64–2.9) | NS |
| min LOD: 0.64 | Alb | 2.0 (0.9–18.6) | 0.7 (0.64–3.6) | NS |
| max LOD: 10000 | CRP | N/A | 1.3 (0.64–4.0) | NS |
| Hb | 1.3 (0.64–18.6) | 0.7 (0.64–2.6) | NS | |
| CXCL10 | BMI | 953 (429–1568) | 359 (226–456) | 0.005 |
| min LOD: 3.2 | Alb | 1030 (774–1816) | 449 (274–554) | < 0.005 |
| max LOD: 10000 | CRP | 445 (263–592) | 551 (367–1030) | NS |
| Hb | 622 (286–1103) | 455 (339–593) | NS | |
| sCD40L | BMI | 5941 (4235–10,000) | 5278 (2808–7197) | NS |
| min LOD: 0.64 | Alb | 7611 (4739–10,000) | 5317 (3973–8380) | NS |
| max LOD: 10000 | CRP | 4866 (3948–6210) | 6323 (4300–10,000) | NS |
| Hb | 5845 (3812–10,000) | 5678 (3973–9481) | NS |
Data are presented as median (interquartile range). Items with more than half cases below or over the LOD were excluded
Abbreviations, GF growth factor, LOD limit of detection, G-CSF granulocyte colony-stimulating factor, BMI body mass index, Alb albumin, CRP C-reactive protein, Hb hemoglobin, IL-1RA interleukin-1 receptor antagonist, CXCL10 CXC motif ligand 10, sCD40L soluble CD40 ligand, N/A not available (median was below or over LOD)
Definitions: low body mass index: < 20 kg/m2; low albumin: < 3.5 g/dL; high C-reactive protein: > 0.3 mg/dL; Anemia: Hb < 12.0 g/dL in males and < 11.0 g/dL in females
*P-values were calculated using Wilcoxon rank sum test. If more than half of one group was lower LOD, we used Fisher’s exact test with cut-off as LOD value. NS, not significant