| ECOG score | Grade I recommendations | Grade II recommendations | Grade III recommendations |
|---|---|---|---|
| 0–1 | Apatinib (Evidence 1A) | Mono-chemotherapy (Evidence 3) | PD-1 monoclonal antibody (Evidence 1A) |
| Encourage participation in clinical trials | |||
| 2 | Encourage participation in clinical trials | Best supportive care | Mono-chemotherapy (Evidence 3) |
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