Site | Stratification | Grade I recommendations | Grade II recommendations | Grade III recommendations |
---|---|---|---|---|
Peritoneal cytology positive (P0CY1)* | ECOG performance score = 0–1, radical resection of the primary lesion and regional lymph nodes | To be treated as recurrent/metastatic gastric cancer or encourage to participate in clinical trials | Standard D2 gastrectomy followed by postoperative chemotherapyb (Evidence 2B) Conversion chemotherapy combined with radical surgeryc (Evidence 2B) |
|
Retroperitoneal lymph node metastasis (station No. 16a2/b1) | ECOG performance score = 0–1, radical resection of the primary lesion and regional lymph nodes | Conversion chemotherapy combined with radical surgeryd (Evidence 2B) | Radical surgery combined with chemoradiotherapy (Evidence 3) | |
Single liver metastasis | ECOG performance score = 0–1, radical resection of the primary lesion and regional lymph nodes | Systemic chemotherapy combined with local treatmente (Evidence 2A) | Surgical resection of primary and metastatic tumor combined with systemic chemotherapyf (Evidence 2B) | |
Ovarian metastasis | ECOG performance score = 0–1, radical resection of the primary lesion and regional lymph nodes | Surgery combined with systemic chemotherapyg (Evidence 2B) |
* P0CY1: No peritoneal metastasis, but the peritoneal cytology is positive for carcinoma cells