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. 2019 Mar 18;18:35. doi: 10.1186/s12933-019-0843-z

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Altered NO bioavailability in type 2 diabetes. Plasma levels of the NO metabolite nitrite (a) before (34 °C) and at the end of hand skin heating (44 °C) in healthy (n = 23), hypertensive (HT; n = 6), type 2 diabetic (T2D; n = 8) and hypertensive type 2 diabetic (HT + T2D; n = 18) subjects. Whole blood levels of reactive oxygen species (ROS) (b) in healthy, hypertensive (HT), type 2 diabetic (T2D) and hypertensive type 2 diabetic (HT + T2D) subjects. Mean values ± SEM are shown. *P < 0.05, **P < 0.01. Linear relationships between the magnitude of radial artery flow-mediated dilatation with the variations in plasma nitrite levels during heating (c) and with ROS levels (d). The dashed lines represent the 95% confidence interval for the regression