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. 2019 Mar 18;18:35. doi: 10.1186/s12933-019-0843-z

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Type 2 diabetes profoundly impaired EETs bioavailability during endothelial stimulation. Plasma levels of epoxyeicosatrienoic acids (EETs) (a), dihydroxyeicosatrienoic acids (DHETs) (b) regioisomers and total EETs + DHETs levels (c) before (34 °C) and at the end of hand skin heating (44 °C), in healthy (n = 28), hypertensive (HT; n = 8), type 2 diabetic (T2D; n = 9) and hypertensive type 2 diabetic (HT + T2D; n = 19) subjects. Mean values ± SEM are shown. *P < 0.05, **P < 0.01. Linear relationships between the magnitude of radial artery flow-mediated dilatation with the variations in plasma EETs + DHETs during heating (d). The dashed lines represent 95% confidence interval for the regression