Fig. 5.

Acute hyperglycemia and hyperinsulinemia altered conduit artery endothelial function in healthy subjects. Variations in radial artery diameter (a) and mean wall shear stress (b) in response to hand skin heating and variation in radial artery diameter in response to glyceryl trinitrate (c) during saline infusion an during the hyperglycemic (HyperGly) and hyperinsulinemic euglycemic (HyperInsu) clamps in 8 healthy subjects. Plasma levels of nitrite (d) and total epoxyeicosatrienoic acids + dihydroxyeicosatrienoic acids (EETs + DHETs) (e) at baseline at 34 °C, at steady-state and at the end of hand skin heating at 44 °C during saline infusion and during the hyperglycemic and hyperinsulinemic euglycemic clamps in 8 healthy subjects. Mean values ± SEM are shown. *P < 0.05, **P < 0.01