Table 1.
Baseline clinical characteristics and pathological features
| Total | IgAN | non-IgAN | p-value | |
|---|---|---|---|---|
| n = 1070 | n = 429 | n = 641 | ||
| Age (years) | 38 ± 15 | 34 ± 12 | 40 ± 16 | <0.001 |
| Male (n, %) | 516 (48.2%) | 171 (39.9%) | 345 (53.8%) | <0.001 |
| Cr (μmol/L) | 84.2 ± 50.1 | 90.3 ± 50.8 | 80.1 ± 50.4 | 0.004 |
| eGFR (ml/min/1.73m2) | 98.1 ± 31.3 | 93.0 ± 32.9 | 101.6 ± 29.8 | <0.001 |
| Urea (mmol/L) | 6.5 ± 3.7 | 6.8 ± 3.7 | 6.3 ± 3.7 | 0.03 |
| Alb (g/L) | 33.2 ± 9.5 | 38.0 ± 6.7 | 30.0 ± 9.7 | <0.001 |
| UA (μmol/L) | 372.7 ± 104.1 | 382.4 ± 105.2 | 366.2 ± 102.8 | 0.01 |
| HUA (n,%) | 415 (38.8%) | 188 (43.8%) | 277 (35.4%) | 0.84 |
| 24 h-u-pro (g/d) | 1.6 (0.5,4.0) | 1.2 (0.5,2.3) | 2.2 (0.5,5.1) | <0.001 |
| SBP | 126.74 ± 17.87 | 126.13 ± 17.52 | 127.13 ± 18.09 | 0.40 |
| DBP | 78.01 ± 12.32 | 77.72 ± 17.16 | 78.19 ± 12.43 | 0.57 |
| hypertension(n,%) | 230 (21.5%) | 85 (19.8%) | 145 (22.6%) | 0.60 |
| Histopathological changes | ||||
| S0 (n,%) | 812 (75.9%) | 237 (55.2%) | 575 (89.7%) | <0.001 |
| S1 (n,%) | 258 (24.1%) | 192 (44.8%) | 66 (10.3%) | |
| T1 (n,%) | 989 (92.4%) | 369 (86.0%) | 620 (96.7%) | <0.001 |
| T2 (n,%) | 68 (6.4%) | 51 (11.9%) | 17 (2.7%) | |
| T3 (n,%) | 13 (1.2%) | 9 (2.1%) | 4 (0.6%) | |
Notes: Cr creatinine, eGFR estimated glomerular filtration rate, Alb albumin, UA uric acid, HUA hyperuricemia, 24 h-u-pro 24 h protein quantitation, SBP systolic blood pressure, DBP diastolic blood pressure, S0: non-segmental glomerular sclerosis, S1: segmental glomerular sclerosis, T1: mild tubular atrophy/interstitial fibrosis, T2: moderate tubular atrophy/interstitial fibrosis, T3: severe tubular atrophy/interstitial fibrosis