Table 2.
Baseline characteristics for sepsis patients, stratified by the presence of autoimmune disease
| Autoimmune disease | No autoimmune disease | P value | |
|---|---|---|---|
| Number of patients | 496 | 5704 | |
| Patient outcomes | |||
| 30-day mortality | 26.61% | 34.55% | < 0.001 |
| Patient characteristics | |||
| Age (mean ± SD) | 64.46 ± 14.64 | 66.21 ± 16.48 | 0.012 |
| Sex (% male) | 44.56% | 57.50% | < 0.001 |
| Race | 0.027 | ||
| White, non-Hispanic | 80.04% | 71.49% | |
| Black, non-Hispanic | 7.26% | 9.34% | |
| Hispanic | 2.02% | 3.30% | |
| Asian/Pacific Islander | 1.61% | 3.00% | |
| Other | 2.42% | 2.58% | |
| Unknown | 6.65% | 10.29% | |
| SOFA at admission (mean ± SD) | 5.63 ± 3.67 | 6.50 ± 3.80 | < 0.001 |
| Elixhauser comorbidity index (mean ± SD) | 9.46 ± 7.74 | 9.75 ± 7.83 | 0.411 |
| Infection site (% pulmonary) | 32.06% | 39.00% | 0.003 |
| Documented bacteremia (% yes) | 16.13% | 18.92% | 0.142 |
| Chronic pre-admission DMARD or prednisone use | 56.05% | 19.78% | < 0.001 |
| Chronic prednisone use | 41.73% | 17.36% | |
| Chronic DMARD use | 34.48% | 5.80% | |
| ICU care unit | 0.694 | ||
| MICU | 63.91% | 62.34% | |
| SICU | 21.57% | 21.27% | |
| CCU | 9.88% | 10.64% | |
| CSRU | 4.64% | 5.75% | |
SOFA Sequential Organ Failure Assessment, DMARD disease-modifying antirheumatic drug, ICU intensive care unit, CCU coronary care unit, CSRU cardiac surgery recovery unit, MICU medical intensive care unit, SICU surgical intensive care unit