Table 4.

Association between autoimmune disease and 30-day mortality according to confounder adjustment strategy

Association between autoimmune disease and 30-day mortality	Sepsis cohort		Septic shock cohort
	OR (95% CI)	P value	OR (95% CI)	P value
All potential confounders adjusteda	0.73 (0.57–0.93)	0.001	0.71 (0.54–0.93)	0.014
SOFA score adjusted	0.79 (0.63–0.98)	0.033	0.73 (0.56–0.93)	0.014

Sepsis cohort—ICU patients with sepsis as defined by Martin criteria. Septic shock cohort—ICU patients with sepsis as defined by Martin criteria and three consecutive mean arterial blood pressure readings below 65 mmHg in a 30-min period or at least one dose of vasopressors during the ICU stay

OR odds ratio, CI confidence interval, SOFA Sequential Organ Failure Assessment

^aOR adjusted for age, sex, race, SOFA score at ICU admission, Elixhauser comorbidity index, pre-admission chronic DMARD or prednisone use, ICU care unit, documented bacteremia, and infection site