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. 2019 Mar 19;20:36. doi: 10.1186/s12863-019-0739-7

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — The illustration of GPI in binary phenotypes. The red line represents the effect of the significant pathway. The three black dot lines represent three situations: positive interaction (L1), no interaction (L0) and negative interaction (L2)