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. 2019 Mar 18;12:31. doi: 10.1186/s13045-019-0710-0

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Summary of study. Early myeloid-derived suppressor cells (HLA-DR^−/lowCD33⁺CD16⁻) expanded by granulocyte colony-stimulating factor derived from G-CSF-mobilized donor PBSCs. This MDSC population suppressed T cell proliferation in vitro and in humanized mouse model, potentially by TGF-β-dependent manner, and promoted Treg generation, which also prevents acute graft-versus-host disease (GVHD) in humanized mouse and might contribute to lower GVHD in patients post-allo-HSCT