Supplementary Table 1.
Characteristics of the 30 Salmonella and 20 Shigella spp. strains and susceptibility to 3 commercial bacteriophage cocktails
| No. | ID strain | Species | Source | Detection Month/Year | Susceptibility according to CLSI |
Bacteriophage Susceptibility a |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AMP | CRO | SXT | CHL | NAL | CIP | INTESTI | Septaphage | PYO | |||||
| 1 | 6301.21 | S. enteritidis | Stool | 08/16 | S | S | S | S | S | S | ++++ | + | R |
| 2 | 6301.22 | S. enteritidis | Stool | 08/16 | S | S | S | S | S | S | R | + | R |
| 3 | 6301.23 | S. enterica subsp. enterica 4,12:i | Stool | 08/16 | S | S | S | S | S | S | R | + | R |
| 4 | 6212.52 | S. enteritidis | Stool | 08/16 | S | S | S | S | S | S | R | + | R |
| 5 | 6212.46 | S. enterica subsp. enterica 4,12:i | Stool | 08/16 | R | S | S | S | S | S | R | + | R |
| 6 | 6212.47 | S. enteritidis | Stool | 08/16 | S | S | S | S | S | S | +++ | + | R |
| 7 | 6211.59 | S. enterica subsp. enterica 6,7:y:- | Stool | 08/16 | S | S | S | S | S | S | ++++ | ++ | +++ |
| 8 | 6211.25 | S. enteritidis | Stool | 08/16 | S | S | S | S | S | S | +++ | + | R |
| 9 | 5804.66 | S. paratyphi A | Blood culture | 04/15 | S | S | S | S | R | I | +++ | + | R |
| 10 | 6102.20 | S. typhimurium | Urine | 01/16 | S | S | S | S | S | S | +++ | R | R |
| 11 | 6103.32 | S. typhimurium | Stool | 02/16 | S | S | S | S | S | S | ++++ | + | R |
| 12 | 6107.71 | S. typhimurium | Stool | 03/16 | S | S | S | S | S | S | ++++ | ++ | R |
| 13 | 6007.27 | S. panama | Stool | 11/15 | S | S | S | S | S | S | ++++ | + | R |
| 14 | 5804.47 | S. paratyphi B | Stool | 04/15 | S | S | S | S | S | S | +++ | + | R |
| 15 | 5602.57 | S. typhimurium | Blood culture | 09/14 | S | S | S | S | S | S | ++++ | ++ | R |
| 16 | 5905.07 | S. enteritidis | Stool | 08/15 | S | S | S | S | S | S | +++ | + | R |
| 17 | 5905.08 | S. enteritidis | Stool | 08/15 | S | S | S | S | S | S | ++++ | ++ | R |
| 18 | 5602.08 | S. enteritidis | Stool | 09/14 | S | S | S | S | S | S | +++ | ++ | R |
| 19 | 5512.03 | S. enteritidis | Blood culture | 08/14 | S | S | S | S | S | S | ++++ | + | R |
| 20 | 5603.72 | S. enteritidis | Blood culture | 09/14 | S | S | S | S | S | S | +++ | ++ | R |
| 21 | 4608.23 | S. paratyphi A | Stool | 12/10 | S | S | S | S | R | S | ++++ | R | R |
| 22 | 4504.56 | S. paratyphi A | Blood culture | 06/10 | S | S | S | S | R | I | ++++ | R | R |
| 23 | 6104.03 | S. paratyphi B | Blood culture | 02/16 | S | S | S | S | S | S | +++ | R | R |
| 24 | 6201.74 | S. paratyphi B | Stool | 05/16 | S | S | S | S | S | S | ++ | + | R |
| 25 | 5902.41 | S. typhimurium | Stool | 07/15 | S | S | S | S | S | S | ++++ | R | R |
| 26 | 5910.36 | S. typhimurium | Stool | 09/15 | S | S | S | S | S | S | ++++ | R | R |
| 27 | 4108.64 | S. oranienburg | Stool | 03/09 | S | S | S | S | S | S | + | R | R |
| 28 | 4310.33 | S. oranienburg | Stool | 12/09 | S | S | S | S | S | S | +++ | + | + |
| 29 | 1490.92 | S. choleraesuis | na | na | - | - | - | - | - | - | ++++ | ++ | ++++ |
| 30 | 6302.34 | S. enteritidis | Stool | 9/16 | S | S | S | S | S | S | ++ | + | R |
| 31 | 6101.40 | S. sonnei | Stool | 01/16 | S | S | R | S | S | S | +++ | + | +++ |
| 32 | 6105.15 | S. sonnei | Stool | 03/16 | S | S | R | S | S | S | +++ | + | +++ |
| 33 | 6108.73 | S. sonnei | Stool | 04/16 | - | - | - | - | - | - | +++ | ++++ | +++ |
| 34 | 6110.62 | S. sonnei | Stool | 04/16 | R | S | R | S | S | S | ++ | + | +++ |
| 35 | 6003.54 | S. flexneri | Stool | 10/15 | - | - | - | - | - | - | ++++ | R | +++ |
| 36 | 6004.50 | S. flexneri | Stool | 11/15 | S | S | R | S | R | S | ++ | R | ++ |
| 37 | 5906.08 | S. flexneri | Stool | 08/15 | S | S | S | S | S | S | ++ | R | ++ |
| 38 | 5509.52 | S. flexneri | Stool | 08/14 | R | S | R | R | S | S | R | R | R |
| 39 | 6306.26 | S. sonnei | Stool | 10/16 | S | S | R | S | S | S | +++ | ++++ | ++ |
| 40 | 5703.48 | S. sonnei | Stool | 11/14 | S | S | R | S | R | R | + | + | + |
| 41 | 5611.08 | S. sonnei | Stool | 11/14 | - | - | - | - | - | - | +++ | ++++ | +++ |
| 42 | 5605.11 | S. sonnei | Stool | 10/14 | S | S | R | S | S | S | ++ | ++ | ++ |
| 43 | 5402.22 | S. sonnei | Stool | 03/14 | S | S | R | S | R | R | ++ | ++ | ++ |
| 44 | 5312.31 | S. sonnei | Stool | 02/14 | R | S | S | S | S | S | ++ | ++ | ++ |
| 45 | 5203.63 | S. sonnei | Stool | 05/13 | S | S | R | S | S | S | ++ | + | ++ |
| 46 | 6209.65 | S. flexneri | Stool | 08/16 | - | - | - | - | - | - | +++ | R | ++ |
| 47 | 4907.58 | S. flexneri | Stool | 02/12 | S | S | R | R | R | R | +++ | R | ++++ |
| 48 | 4706.22 | S. flexneri | Stool | 04/11 | S | S | R | S | R | S | + | R | ++ |
| 49 | 4611.14 | S. flexneri | Stool | 01/11 | S | S | R | S | S | S | ++ | R | ++ |
| 50 | 4512.64 | S. flexneri | Stool | 09/10 | R | S | S | R | S | S | +++ | R | ++ |
Note. AMP, ampicillin; CRO, ceftriaxone; SXT, cotrimoxazole; CHL, chloramphenicol; NAL, nalidixic acid; CIP, ciprofloxacin; R, resistant; I, intermediate; S, susceptible; na, not available; -, not tested.
a Strains were defined as susceptible to the bacteriophages when confluent lysis (ie, complete clearing: ++++), semi-confluent lysis (ie, clearing throughout but with faint hazy background: +++), opaque lysis (ie, turbidity throughout the cleared zone: ++), taches vierges (ie, a few individual plaques: +) were recorded. Strains showing no activity (ie, no clearing “R”) were defined as resistant.