Table 2.

The neuroprotection of active TCM components involves anti- inflammatory responses in IRI rodent models.

TCM-compound	Rodent type	Anti-inflammatory target	Cerebral IRI-model	Reference
Ferulic acid	Rat	ICAM-1↓, NF-κB↓, superoxide radicals↓, MPO↓	MCAO	Cheng et al., 2008
Cholalic acid/hyodeoxycholalic acid	Rat	IL-1β↓, TNF-α↓	MCAO	Hua et al., 2009
Curcumin	Rat	IL-1↓, TLR4↓, p-38↓, p-p38↓	MCAO	Huang et al., 2018
Schisandrin B	Rat	IL-1β↓, TNF-α↓	MCAO	Lee et al., 2012
Puerarin	Rat	TLR4↓, MyD88↓, NF-κB↓, TNF-α↓	MCAO	Zhou et al., 2014
Matrine	Rat	NF-κB p65↓, p53↓, c-Myc↓	MCAO	Xu et al., 2012
Ampelopsin	Rat	IL-1β↓, TNF-α↓	MCAO	Ye et al., 2017
Icariside II	Rat	IL-1β↓, TGF-β1↓, NF-κB↓, PPARα↑, PPARγ↑, IκB-α↓	MCAO	Deng et al., 2016; Xiong D. et al., 2016
Tanshinone IIA	Mice/gerbils	SOD↓, MDA↓, iNOS↓, TNF-α↓, NO↓, NF-κB↓, IL-4↑, IL-13↑	MCAO/BCCAO	Dong et al., 2009; Park et al., 2014
Salvianolic acid B	Mice	GFAP↓, Iba1↓, IL-1β↓, IL-6↓, TNF-α↓, Cleaved-caspase 3↓	MCAO	Fan et al., 2018
Astragaloside IV	Mice/rat	TLR4↓, MyD88↓, TRIF↓, TRAF6↓, NF-κB↓, NO↓, TNF-α↓IL-1β	BCCAO/MCAO	Li M. et al., 2017; Xu E. et al., 2017
Salvianolic acid B and puerarin	Rat	TNF-α↓, IL-1β↓, IL-6↓, TLR4↓, MyD88↓, NF-κB↓	MCAO	Ling et al., 2018
Magnolol	Mice	NO↓, TNF-α↓, NF-κB p65↓	MCAO	Liu et al., 2017
Scutellarin	Mice	IL-1β↓, TNF-α↓, iNOS↓, CSF↓, NF-κB↓	MCAO	Yuan et al., 2016; Wu et al., 2017
Honokiol	Mice	NO↓, TNF-α↓, RANTES/CCL5↓	BCCAO	Zhang et al., 2013
Borneol	Mice	iNOS↓, TNF-α↓, NO↓	MCAO	Chang et al., 2017
Paeonol	Rat	TLR2↓, TLR4↓, Iba1↓, NF-κB (p50)↓, IL-1β↓	MCAO	Liao et al., 2016
Brazilein	Mice	NOD2↓, TNF-α↓	BCCAO	Yan et al., 2016
Tetramethylpyrazine	Rat	TNF-α↓, IL-8↓, HMGB1↓, TLR4↓, NO↓, NOS↓	MCAO	Zhang C. et al., 2014, 2018; Chang et al., 2015
MLC901	Mice	IL-1β↓, IL-6↓, TNFα↓, TLR4↓	MCAO	Widmann et al., 2018
β-Asaron	Rat	IL-1β↓, TNF-α↓	MCAO	He et al., 2018