Table 2.

Estimates of BP heritability explained by tissue-specific KD subnetworks.

Traits	$h_g^2\left(\%SE\right)$*	$h_{\text{pub}}^2(95\%\text{CI})$†	$h_{\text{GWAS}}^2(\%\text{SE})$‡	Networks	$h_{KD\_\text{sub}}^2\left(\%\text{SE}\right)$§	$h_{\text{random}}^2\left(\%\text{SE}\right)$||	P-values of top KD subnetworks
SBP	45.5 (0.82)	56 (53, 59)	1.36 (0.20)	Adipose	19.76 (0.61)	5.12 (0.76)	<1.0e-4
				Artery	16.66 (0.37)	4.61 (0.82)	<1.0e-4
				Blood	18.24 (0.51)	4.82 (0.81)	<1.0e-4
				Brain	8.36 (0.35)	3.74 (0.66)	<1.0e-4
				Cardiac Muscle	13.32 (0.34)	3.95 (0.76)	<1.0e-4
				Kidney	7.65 (0.67)	3.80 (0.72)	<1.0e-4
				Liver	17.35 (0.40)	4.67 (0.65)	<1.0e-4
				PPI	22.65 (0.57)	5.10 (0.65)	<1.0e-4
DBP	62.3 (0.81)	61 (58, 64)	1.49 (0.28)	Adipose	21.75 (0.28)	7.42 (0.89)	<1.0e-4
				Artery	17.07 (0.21)	5.25 (0.76)	<1.0e-4
				Blood	23.34 (0.35)	8.37 (0.75)	<1.0e-4
				Brain	15.06 (0.24)	4.65 (0.63)	<1.0e-4
				Cardiac Muscle	15.55 (0.36)	4.45 (0.67)	<1.0e-4
				Kidney	8.90 (0.56)	4.60 (0.65)	<1.0e-4
				Liver	18.39 (0.45)	4.67 (0.83)	<1.0e-4
				PPI	24.73 (0.41)	6.26 (0.75)	<1.0e-4

^*Total SNP heritability estimated by HESS;

^†heritability of SBP/DBP based on reports by a recent study detailed in Methods;

^‡heritability explained by GWAS hits (P < 5.0E-8);

^§heritability explained by the subnetworks of the top KDs in each tissue network (the tissue-specific subnetworks were listed in Supplementary Table 6);

^||average values of heritability explained by subnetworks of random genes that are not KDs; and P-values represent comparisons between top KD and random gene subnetworks.