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Design of the Keap1‐binding loops grafted into the CTPR scaffold
| CTPR | Loop sequence |
|---|---|
| Consensus Nrf2 CTPR2 | DPNNLDEETGEFLDPNN |
| Flexible Nrf2 CTPR2 | DPNNGGLDEETGEFLGGDPNN |
| Charge Nrf2 CTPR2 | DPDNLDEETGEFLDPDN |
| CIDER NRf2 CTPR2 | DPNNLDEETGEFLDPRN |
The sequence of the “native” CTPR loop is in bold. The sequence corresponding to the Nrf2 peptide is shown in italics. The other residues, relating to the design strategy, are shown in plain font.
